Abstract
Dual-specificity phosphatases (DUSPs) is an emerging subclass of the protein tyrosine phosphatase gene superfamily, a heterogeneous group of protein phosphatases that can dephosphorylate both phosphotyrosine and phosphoserine/phosphothreonine residues within the one substrate. Recently, a series of investigations of DUSPs defined their essential roles in cell proliferation, cancer and the immune response. This review will focus on DUSP2, its involvement in different diseases and its potential as a therapeutic target.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Adaptive Immunity
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Animals
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Biomarkers
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Dual Specificity Phosphatase 2 / genetics
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Dual Specificity Phosphatase 2 / immunology
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Dual Specificity Phosphatase 2 / metabolism*
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Humans
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Infections / diagnosis
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Infections / genetics
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Infections / metabolism
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Inflammation / diagnosis
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Inflammation / genetics
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Inflammation / metabolism
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MAP Kinase Signaling System
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Neoplasms / diagnosis
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Neoplasms / genetics
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Neoplasms / metabolism
Substances
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Biomarkers
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Dual Specificity Phosphatase 2