Abstract
Aging affects all compartments of the immune response and has a major impact on transplant outcome and organ quality. Although clinical trials in the aging transplant population remain rare, our current understanding of immunosenescence provides a basis for an age-adapted immunosuppression and organ allocation with the goal to optimize utilization and to improve outcomes in older recipients. From a more general perspective, understanding the mechanisms and consequences of immunosenescence will have a broad impact on immune therapies in and beyond transplantation.
© 2012 The Authors Transplant International © 2012 European Society for Organ Transplantation.
Publication types
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Comparative Study
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Age Factors
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Aged
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Aging / immunology*
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Aging / physiology
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Graft Rejection
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Graft Survival
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Humans
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Immune Tolerance
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Immunity, Innate / physiology*
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Immunosuppression Therapy
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Kidney Transplantation / adverse effects
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Kidney Transplantation / immunology
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Kidney Transplantation / methods
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Liver Transplantation / adverse effects
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Liver Transplantation / immunology
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Liver Transplantation / methods
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Living Donors
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Middle Aged
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Organ Transplantation / adverse effects
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Organ Transplantation / methods*
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Prognosis
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Risk Assessment
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Tissue Donors
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Transplantation Immunology / immunology*
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Transplantation Immunology / physiology