[Synthesis and anti-tumor properties of myelopeptide MP-1]

L A Fonina; E M Treshchalina; R G Belevskaia; A A Az'muko; M A Efremov; L A Sedakova; E A Kirilina

doi:10.1134/s1068162012040073

[Synthesis and anti-tumor properties of myelopeptide MP-1]

Bioorg Khim. 2012 Jul-Aug;38(4):406-12. doi: 10.1134/s1068162012040073.

[Article in Russian]

Authors

L A Fonina, E M Treshchalina, R G Belevskaia, A A Az'muko, M A Efremov, L A Sedakova, E A Kirilina

PMID: 23189554
DOI: 10.1134/s1068162012040073

Abstract

We have studied anti-tumor properties of bone marrow derived peptide Phe-Leu-Gly-Phe-Pro-Thr (MP-1) synthesized by classical methods. It was shown that MP-1 enhanced the effect ofcytostatic therapy of lymphatic leukemia P388 and increased latent growth period of P388 tumors implanted in irradiated mice. MP-1 also decreased metastasis of mouse breast adenocarcinoma Ca-755 after surgery.

Publication types

English Abstract

MeSH terms

Animals
Antineoplastic Agents* / administration & dosage
Antineoplastic Agents* / chemical synthesis
Cell Line, Tumor
Cisplatin / administration & dosage
Combined Modality Therapy
Leukemia P388* / drug therapy
Leukemia P388* / radiotherapy
Mice
Oligopeptides* / administration & dosage
Oligopeptides* / chemical synthesis

Substances

Antineoplastic Agents
Oligopeptides
myelopeptides
Cisplatin