4,5-seco-guaiane and a nine-membered sesquiterpene lactone from Holostylis reniformis

Molecules. 2012 Nov 27;17(12):14046-57. doi: 10.3390/molecules171214046.

Abstract

Root extracts of Holostylis reniformis (Aristolochiaceae) yielded three new natural sesquiterpenes, a sesquiterpene with an unusual carbon skeleton, 4,5-seco-guaiane (7-epi-11-hydroxychabrolidione A, 1), a nine-membered lactone with new carbon skeleton (holostylactone, 2), and a new megastigmane [(6S,7E)-6,9-dihydroxy-10-(2'-hydroxy-ethoxy)-4,7-megastigmadien-3-one, 3], together with bulnesol and sitosterol-3-O-β-D-glucopyranoside. The structures of these compounds were determined by spectroscopic analyses and B3LYP/STO-3G** theoretical studies.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aristolochiaceae / chemistry*
  • Lactones* / chemistry
  • Lactones* / isolation & purification
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Plant Extracts / chemistry
  • Plant Roots / chemistry
  • Sesquiterpenes* / chemistry
  • Sesquiterpenes* / isolation & purification
  • Sesquiterpenes, Guaiane / chemistry*
  • Sesquiterpenes, Guaiane / isolation & purification

Substances

  • Lactones
  • Plant Extracts
  • Sesquiterpenes
  • Sesquiterpenes, Guaiane
  • guaiane