Size-controlled and biocompatible Gd2 O3 nanoparticles for dual photoacoustic and MR imaging

Adv Healthc Mater. 2012 Sep;1(5):657-60. doi: 10.1002/adhm.201200103. Epub 2012 Jul 12.

Abstract

The synthesis, characterization, and functional evaluation of new size-controlled and biocompatible Gd(2) O(3) nanoparticles as a bimodal contrast agent for use in photoacoustic (PA) and magnetic resonance (MR) imaging are reported. These nanoparticles show a clear PA image by themselves, without conjugation with gold, rare earth metals, or dyes. Relaxivity measurement by MR imaging clearly shows that their relaxivity, r(1) , is twice that of clinically available Gd-DTPA.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biocompatible Materials* / chemical synthesis
  • Contrast Media / chemical synthesis
  • Gadolinium* / chemistry
  • Magnetic Resonance Imaging / methods*
  • Mice
  • Microscopy, Fluorescence / methods*
  • Nanoparticles / chemistry*
  • Particle Size
  • Photoacoustic Techniques / methods*
  • Subtraction Technique

Substances

  • Biocompatible Materials
  • Contrast Media
  • gadolinium oxide
  • Gadolinium