Abstract
VEGF-binding peptide ligands are incorporated into hydrogel microspheres and reduce the amount of growth factor in solution. VEGF binding affinity is enhanced by creating ligands with a dimer structure. The spheres are able to knock down VEGF-mediated HUVEC growth and reduce calcium signaling. The binding interaction is reversible, allowing the spheres to be used as a VEGF delivery vehicle.
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Cells, Cultured
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Drug Carriers / chemistry*
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Endothelial Cells / drug effects*
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Endothelial Cells / metabolism*
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Humans
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Intercellular Signaling Peptides and Proteins / metabolism*
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Ligands
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Peptides / pharmacology*
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Signal Transduction / drug effects
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Signal Transduction / physiology*
Substances
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Drug Carriers
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Intercellular Signaling Peptides and Proteins
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Ligands
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Peptides