Jejunal tube feeding is an important and promising method for nutrition support in pancreatoduodenectomy. The indications for this kind of feeding are increasing and include a variety of clinical conditions, such as gastroparesis, acute pancreatitis, gastric outlet stenosis, hyperemesis (including gravida), recurrent aspiration, tracheoesophageal fistula and stenosis in gastroenterostomy. This review discusses the jejunal tube feeding indications and contraindications, advantages and disadvantages, and provides an overview of the techniques of placement of various devices. Nutritional support is one of the major constituents of the support therapy protocol. We completely agree with evidence-based recommendation that enteral feeding should be preferred whenever possible. Jejunal tube feeding could be successfully applied in cases when tube feeding is indicated in pancreatoduodenectomy.