Abstract
We compared transmission characteristics for prions from L-type bovine spongiform encephalopathy and MM2-cortical sporadic Creutzfeldt-Jakob disease in the Syrian golden hamster and an ovine prion protein-transgenic mouse line and isolated distinct prion strains. Our findings suggest the absence of a causal relationship between these diseases, but further investigation is warranted.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Brain / metabolism
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Brain / pathology
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Cattle
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Creutzfeldt-Jakob Syndrome / mortality
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Creutzfeldt-Jakob Syndrome / pathology
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Creutzfeldt-Jakob Syndrome / transmission*
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Cricetinae
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Encephalopathy, Bovine Spongiform / mortality
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Encephalopathy, Bovine Spongiform / pathology
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Encephalopathy, Bovine Spongiform / transmission*
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Humans
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Mice
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Mice, Transgenic
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Prions / metabolism
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Prions / pathogenicity*