Benzazoles from aliphatic amines and o-amino/mercaptan/hydroxyanilines: elemental sulfur as a highly efficient and traceless oxidizing agent

Org Lett. 2012 Dec 7;14(23):5948-51. doi: 10.1021/ol302856w. Epub 2012 Nov 21.

Abstract

A novel remarkably simple solvent-free and catalyst-free synthesis of benzazoles from alkylamines and o-hydroxy/amino/mercaptan anilines using elemental sulfur as traceless oxidizing agent has been developed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amines / chemistry*
  • Benzene Derivatives / chemical synthesis*
  • Benzene Derivatives / chemistry*
  • Combinatorial Chemistry Techniques
  • Heterocyclic Compounds, 2-Ring / chemical synthesis*
  • Heterocyclic Compounds, 2-Ring / chemistry
  • Molecular Structure
  • Oxidants / chemistry*
  • Sulfur Compounds / chemistry*

Substances

  • Amines
  • Benzene Derivatives
  • Heterocyclic Compounds, 2-Ring
  • Oxidants
  • Sulfur Compounds