A common diaryl ether intermediate for the gram-scale synthesis of oxazine and xanthene fluorophores

Angew Chem Int Ed Engl. 2013 Jan 7;52(2):650-4. doi: 10.1002/anie.201205369. Epub 2012 Nov 21.

Abstract

Common ground: copper-catalyzed coupling reactions can be used for the high-yielding preparation of widely used oxazine and xanthene fluorophores from a common diaryl ether intermediate on a gram-scale. This general approach may facilitate the future development of novel fluorophores and probes with unique properties.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Cyclization
  • Ether / chemistry
  • Fluorescent Dyes / chemical synthesis*
  • Fluorescent Dyes / chemistry
  • Oxazines / chemical synthesis*
  • Oxazines / chemistry
  • Xanthenes / chemical synthesis*
  • Xanthenes / chemistry

Substances

  • Fluorescent Dyes
  • Oxazines
  • Xanthenes
  • Ether