The purpose of this integrative review is to describe, compare, and synthesize traditional and computer-based family interventions that aim to change adolescents' risky sexual behaviors and substance abuse. Family interventions have been shown to generate protective effects for preventing adolescents from risky behaviors. It is not clear, however, whether there are significant differences or similarities in the designs and effects of traditional and computer-based family interventions. An integrative literature review was conducted to describe and compare the designs and effects of traditional and computer-based family interventions. Both interventions have generated significant effects on reducing risky behavior among adolescents. Interventions guided by theory, tailored to participants' culture/gender, and which included sufficient boosting dosages in their designs demonstrated significant short- or long-term effects in terms of reducing adolescents' risky behaviors. Regardless of delivery method, well-designed family interventions are noted to maximize familial protective effects and reduce risky behaviors.