Enamine catalysis in flow with an immobilized peptidic catalyst

ChemSusChem. 2013 Feb;6(2):242-5. doi: 10.1002/cssc.201200740. Epub 2012 Nov 19.

Abstract

Pep talk: An immobilized peptidic catalyst achieves more than 600 turnovers in a continuous-flow system, allowing the production of chiral γ-nitroaldehydes with excellent stereoselectivities on a scale of >450 mmol (>100 g). Such a high efficiency opens the way for more practical applications of enamine catalysis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aldehydes / chemistry
  • Amines / chemistry*
  • Immobilized Proteins / chemistry*
  • Peptides / chemistry*
  • Stereoisomerism
  • Substrate Specificity

Substances

  • Aldehydes
  • Amines
  • Immobilized Proteins
  • Peptides