Abstract
Series of new ring-substituted styrylquinolines and two oxorhenium complexes were prepared and characterized. The compounds were analyzed using RP-HPLC to determine lipophilicity. Primary in vitro screening of the synthesized compounds was performed against fungal and bacterial strains. Some compounds were active against bacteria at micromolar level and against fungi at submicromolar level. Compounds 5,7-dichloro-2-[2-(2-ethoxyphenyl)vinyl]quinolin-8-ol expressed excellent antifungal activity comparable with or higher than the standard fluconazole as well as antibacterial activity against Staphylococcus strains comparable with or higher than the standards bacitracin, penicillin and ciprofloxacin. The structure-activity relationships are discussed.
Copyright © 2012 Elsevier Ltd. All rights reserved.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Anti-Bacterial Agents / chemical synthesis
-
Anti-Bacterial Agents / chemistry
-
Anti-Bacterial Agents / pharmacology
-
Anti-Infective Agents / chemical synthesis
-
Anti-Infective Agents / chemistry*
-
Anti-Infective Agents / pharmacology*
-
Antifungal Agents / chemical synthesis
-
Antifungal Agents / chemistry
-
Antifungal Agents / pharmacology
-
Hydrocarbons, Halogenated / chemical synthesis
-
Hydrocarbons, Halogenated / chemistry
-
Hydrocarbons, Halogenated / pharmacology
-
Microbial Sensitivity Tests
-
Molecular Structure
-
Quinolines / chemical synthesis
-
Quinolines / chemistry*
-
Quinolines / pharmacology*
-
Structure-Activity Relationship
Substances
-
Anti-Bacterial Agents
-
Anti-Infective Agents
-
Antifungal Agents
-
Hydrocarbons, Halogenated
-
Quinolines
-
styrylquinoline