Abstract
Two new dihydroflavonol derivatives, macarecurvatins A and B, have been isolated from the leaves of Macaranga recurvata (Euphorbiaceaae), along with the known compounds diisoprenylaromadendrin, glyasperin A and broussoflavonol F. The structures of the new compounds were determined on the basis of spectroscopic evidence. Upon cytotoxic evaluation against P-388 cells, macarecurvatin B showed strong activity with an IC50 of 0.83 microM.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Antineoplastic Agents, Phytogenic / chemistry
-
Antineoplastic Agents, Phytogenic / isolation & purification
-
Antineoplastic Agents, Phytogenic / pharmacology
-
Cell Line, Tumor
-
Euphorbiaceae / chemistry*
-
Flavonols / chemistry*
-
Flavonols / isolation & purification
-
Flavonols / pharmacology
-
Leukemia P388 / drug therapy
-
Magnetic Resonance Spectroscopy
-
Mice
-
Plant Leaves / chemistry
-
Spectrophotometry, Ultraviolet
Substances
-
Antineoplastic Agents, Phytogenic
-
Flavonols
-
macarecurvatin A
-
macarecurvatin B