Abstract
A 63-year-old woman suddenly developed central retinal artery occlusion following a slight fever while being treated with methimazole (MMI) for hyperthyroidism. She was diagnosed to have anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) based on increased inflammatory reactions with positive myeloperoxidase-ANCA in the serum. Her visual acuity remained low despite immediate treatment with corticosteroids and cyclophosphamide after cessation of MMI, which may have played a role in the pathogenesis of AAV. Central retinal artery occlusion is a rare manifestation of AAV; however, it is important with regard to the possibility of serious sequelae.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / diagnosis
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Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / drug therapy
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Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / etiology*
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Anticoagulants / therapeutic use
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Antithyroid Agents / adverse effects*
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Dalteparin / therapeutic use
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Female
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Humans
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Hyperthyroidism / drug therapy
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Immunosuppressive Agents / therapeutic use
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Methimazole / adverse effects*
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Middle Aged
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Retinal Artery Occlusion / diagnosis
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Retinal Artery Occlusion / drug therapy
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Retinal Artery Occlusion / etiology*
Substances
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Anticoagulants
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Antithyroid Agents
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Immunosuppressive Agents
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Methimazole
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Dalteparin