Involvement of lysosomal exocytosis in the excretion of mesoporous silica nanoparticles and enhancement of the drug delivery effect by exocytosis inhibition

Rolando E Yanes; Derrick Tarn; Angela A Hwang; Daniel P Ferris; Sean P Sherman; Courtney R Thomas; Jie Lu; April D Pyle; Jeffrey I Zink; Fuyuhiko Tamanoi

doi:10.1002/smll.201201811

Involvement of lysosomal exocytosis in the excretion of mesoporous silica nanoparticles and enhancement of the drug delivery effect by exocytosis inhibition

Small. 2013 Mar 11;9(5):697-704. doi: 10.1002/smll.201201811. Epub 2012 Nov 14.

Authors

Rolando E Yanes¹, Derrick Tarn, Angela A Hwang, Daniel P Ferris, Sean P Sherman, Courtney R Thomas, Jie Lu, April D Pyle, Jeffrey I Zink, Fuyuhiko Tamanoi

Affiliation

¹ Department of Microbiology, California NanoSystems Institute, Jonsson Comprehensive Cancer Center, University of California, Los Angeles, 405 Hilgard Avenue, Los Angeles, CA 90095, USA.

Abstract

The exocytosis of phosphonate modified mesoporous silica nanoparticles (P-MSNs) is demonstrated and lysosomal exocytosis is identified as the mechanism responsible for this event. Regulation of P-MSN exocytosis can be achieved by inhibiting or accelerating lysosomal exocytosis. Slowing down P-MSN exocytosis enhances the drug delivery effect of CPT-loaded P-MSNs by improving cell killing.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Cell Line
Drug Carriers / chemistry*
Exocytosis / physiology
Humans
Lysosomes / chemistry*
Nanoparticles / chemistry*
Silicon Dioxide / chemistry*

Substances

Drug Carriers
Silicon Dioxide

Abstract

Publication types

MeSH terms

Substances

Grants and funding