Synthesis of fluorescent ristocetin aglycon derivatives with remarkable antibacterial and antiviral activities

Eur J Med Chem. 2012 Dec:58:361-7. doi: 10.1016/j.ejmech.2012.10.030. Epub 2012 Oct 25.

Abstract

Isoindole and benzoisoindole derivatives of ristocetin aglycon have been prepared by reaction with o-phthalaldehyde or naphthalene-2,3-dialdehyde and various thiols. The new compounds exhibited potent antibacterial and anti-influenza virus activity. The cluster forming and fluorescent properties of the aglycon derivatives were also studied.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / chemical synthesis
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology*
  • Antiviral Agents / chemical synthesis
  • Antiviral Agents / chemistry
  • Antiviral Agents / pharmacology*
  • Dose-Response Relationship, Drug
  • Doxorubicin / analogs & derivatives*
  • Doxorubicin / chemical synthesis
  • Doxorubicin / chemistry
  • Doxorubicin / pharmacology
  • Fluorescence*
  • Gram-Positive Bacteria / drug effects*
  • Microbial Sensitivity Tests
  • Molecular Conformation
  • Orthomyxoviridae / drug effects*
  • Structure-Activity Relationship

Substances

  • Anti-Bacterial Agents
  • Antiviral Agents
  • ristocetin aglycon
  • Doxorubicin