Abstract
Heterologous expression of the barbamide biosynthetic gene cluster, obtained from the marine cyanobacterium Moorea producens, in the terrestrial actinobacterium Streptomyces venezuelae, resulted in the production of a new barbamide congener 4-O-demethylbarbamide, demonstrating the potential of this approach for investigating the assembly and tailoring of complex marine natural products.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Biological Products / chemistry
-
Biological Products / isolation & purification*
-
Cyanobacteria / chemistry*
-
Marine Biology
-
Molecular Structure
-
Multigene Family
-
Stereoisomerism
-
Streptomyces / chemistry
-
Thiazoles / chemistry*
-
Thiazoles / isolation & purification*
Substances
-
Biological Products
-
Thiazoles
-
barbamide