Heterologous production of 4-O-demethylbarbamide, a marine cyanobacterial natural product

Org Lett. 2012 Dec 7;14(23):5824-7. doi: 10.1021/ol302575h. Epub 2012 Nov 13.

Abstract

Heterologous expression of the barbamide biosynthetic gene cluster, obtained from the marine cyanobacterium Moorea producens, in the terrestrial actinobacterium Streptomyces venezuelae, resulted in the production of a new barbamide congener 4-O-demethylbarbamide, demonstrating the potential of this approach for investigating the assembly and tailoring of complex marine natural products.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biological Products / chemistry
  • Biological Products / isolation & purification*
  • Cyanobacteria / chemistry*
  • Marine Biology
  • Molecular Structure
  • Multigene Family
  • Stereoisomerism
  • Streptomyces / chemistry
  • Thiazoles / chemistry*
  • Thiazoles / isolation & purification*

Substances

  • Biological Products
  • Thiazoles
  • barbamide