Copper-promoted trifluoromethylation of primary and secondary alkylboronic acids

Jun Xu; Bin Xiao; Chuan-Qi Xie; Dong-Fen Luo; Lei Liu; Yao Fu

doi:10.1002/anie.201206681

Copper-promoted trifluoromethylation of primary and secondary alkylboronic acids

Angew Chem Int Ed Engl. 2012 Dec 7;51(50):12551-4. doi: 10.1002/anie.201206681. Epub 2012 Nov 9.

Authors

Jun Xu¹, Bin Xiao, Chuan-Qi Xie, Dong-Fen Luo, Lei Liu, Yao Fu

Affiliation

¹ Department of Chemistry, University of Science and Technology of China, Hefei 230026, China.

PMID: 23143929
DOI: 10.1002/anie.201206681

Abstract

New couple: The Cu-promoted trifluoromethylation of primary and secondary alkylboronic acids with TMSCF(3) extends the scope of transition-metal-catalyzed trifluoromethylation reactions to sp(3)-hybridized carbon centers. It also represents one of the first examples for Cu-catalyzed C-C cross-coupling reactions of alkylboronic acid derivatives.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Boronic Acids / chemistry*
Catalysis
Copper / chemistry*
Crystallography, X-Ray
Fluorine / chemistry*
Molecular Conformation

Substances

Boronic Acids
Fluorine
Copper