Abstract
Several in vitro DNA microarray studies have shown the importance of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) in skin sensitization. Nevertheless, the exact in vivo role of the Nrf2-Keap1 pathway during the induction of skin sensitization remains unknown. To study the function of Nrf2, a local lymph node assay was performed in wild-type and Nrf2-deficient mice using 2,4-dinitrochlorobenzene. The Nrf2-deficient mice show a more pronounced response, indicating that Nrf2 is involved in dampening the induction of skin sensitization.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Allergens / toxicity*
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Animals
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Cell Count
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Dermatitis, Allergic Contact / etiology*
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Dermatitis, Allergic Contact / genetics
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Dermatitis, Allergic Contact / pathology
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Dinitrochlorobenzene / toxicity
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Irritants / toxicity
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Local Lymph Node Assay*
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Lymph Nodes / drug effects*
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Lymph Nodes / pathology
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Lymphocytes / drug effects
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Lymphocytes / metabolism
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Lymphocytes / pathology
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Mice
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Mice, Inbred C57BL
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Mice, Knockout
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NF-E2-Related Factor 2 / deficiency*
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NF-E2-Related Factor 2 / genetics
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Skin Tests
Substances
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Allergens
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Dinitrochlorobenzene
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Irritants
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NF-E2-Related Factor 2
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Nfe2l2 protein, mouse