Induction of skin sensitization is augmented in Nrf2-deficient mice

Arch Toxicol. 2013 Apr;87(4):763-6. doi: 10.1007/s00204-012-0976-2. Epub 2012 Nov 11.

Abstract

Several in vitro DNA microarray studies have shown the importance of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) in skin sensitization. Nevertheless, the exact in vivo role of the Nrf2-Keap1 pathway during the induction of skin sensitization remains unknown. To study the function of Nrf2, a local lymph node assay was performed in wild-type and Nrf2-deficient mice using 2,4-dinitrochlorobenzene. The Nrf2-deficient mice show a more pronounced response, indicating that Nrf2 is involved in dampening the induction of skin sensitization.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Allergens / toxicity*
  • Animals
  • Cell Count
  • Dermatitis, Allergic Contact / etiology*
  • Dermatitis, Allergic Contact / genetics
  • Dermatitis, Allergic Contact / pathology
  • Dinitrochlorobenzene / toxicity
  • Irritants / toxicity
  • Local Lymph Node Assay*
  • Lymph Nodes / drug effects*
  • Lymph Nodes / pathology
  • Lymphocytes / drug effects
  • Lymphocytes / metabolism
  • Lymphocytes / pathology
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • NF-E2-Related Factor 2 / deficiency*
  • NF-E2-Related Factor 2 / genetics
  • Skin Tests

Substances

  • Allergens
  • Dinitrochlorobenzene
  • Irritants
  • NF-E2-Related Factor 2
  • Nfe2l2 protein, mouse