Cytokinesis: RhoGEFs control a developmental cleavage switch

Ling-Rong Kao; Timothy Megraw

doi:10.1016/j.cub.2012.09.031

Cytokinesis: RhoGEFs control a developmental cleavage switch

Curr Biol. 2012 Nov 6;22(21):R916-7. doi: 10.1016/j.cub.2012.09.031.

Authors

Ling-Rong Kao¹, Timothy Megraw

Affiliation

¹ Florida State University, College of Medicine, Department of Biomedical Sciences, 1115 West Call Street, Tallahassee, FL 32306-4300, USA.

PMID: 23137687
DOI: 10.1016/j.cub.2012.09.031

Abstract

New findings provide evidence that developmentally staged RhoGEFs control assembly of two alternative forms of cleavage furrows: the 'Rappaport' furrows, which govern division of Drosophila syncytial cortical division cycles, and conventional spindle-directed furrows.

Publication types

Comment

MeSH terms

Animals
Cell Cycle Proteins
Cleavage Stage, Ovum / metabolism*
Drosophila / embryology*
Drosophila Proteins / metabolism*
Embryo, Nonmammalian / metabolism*
Guanine Nucleotide Exchange Factors / metabolism*
Rho Guanine Nucleotide Exchange Factors
rho GTP-Binding Proteins / metabolism*

Substances

Cell Cycle Proteins
Drosophila Proteins
Guanine Nucleotide Exchange Factors
Pbl protein, Drosophila
Rho Guanine Nucleotide Exchange Factors
sav protein, Drosophila
rho GTP-Binding Proteins