Critical roles of RNA-binding proteins in miRNA biogenesis in Arabidopsis

RNA Biol. 2012 Dec;9(12):1424-8. doi: 10.4161/rna.22740. Epub 2012 Nov 7.

Abstract

MicroRNAs (miRNAs) are key regulators of gene expression and play critical roles in modulating metabolism, development and physiology in animals and plants. miRNA levels are transcriptionally and post-transcriptionally controlled for their proper function. Recent studies have shown that RNA-binding proteins play important roles in producing miRNAs by affecting the accurate and/or efficient processing of precursors of miRNAs. Many of these RNA-binding proteins also have roles in general RNA metabolism, indicating potential connections between miRNA biogenesis and other RNA metabolism. Here, we focus on the function of several RNA-binding proteins in miRNA biogenesis in Arabidopsis.

Keywords: Arabidopsis; CBP80/CBP20; DCL1; DDL; HYL1; RNA-binding protein; SE; TOUGH; miRNA biogenesis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Arabidopsis / genetics
  • Arabidopsis / metabolism*
  • Arabidopsis Proteins / genetics
  • Arabidopsis Proteins / metabolism
  • Calcium-Binding Proteins / genetics
  • Calcium-Binding Proteins / metabolism
  • Carrier Proteins / genetics
  • Carrier Proteins / metabolism
  • Gene Expression Regulation, Plant
  • Genes, Plant
  • Intercellular Signaling Peptides and Proteins / genetics
  • Intercellular Signaling Peptides and Proteins / metabolism
  • Membrane Proteins / genetics
  • Membrane Proteins / metabolism
  • MicroRNAs / genetics
  • MicroRNAs / metabolism*
  • Protein Binding
  • Protein Interaction Mapping
  • RNA Processing, Post-Transcriptional
  • RNA, Plant / genetics
  • RNA, Plant / metabolism*
  • RNA, Small Interfering / genetics
  • RNA, Small Interfering / metabolism
  • RNA-Binding Proteins / genetics
  • RNA-Binding Proteins / metabolism
  • Serrate-Jagged Proteins

Substances

  • Arabidopsis Proteins
  • CBP20 protein, Arabidopsis
  • Calcium-Binding Proteins
  • Carrier Proteins
  • DAWDLE protein, Arabidopsis
  • HYL1 protein, Arabidopsis
  • Intercellular Signaling Peptides and Proteins
  • Membrane Proteins
  • MicroRNAs
  • RNA, Plant
  • RNA, Small Interfering
  • RNA-Binding Proteins
  • SE protein, Arabidopsis
  • Serrate-Jagged Proteins
  • TOUGH protein, Arabidopsis