Disordering of phospholipid headgroups induced by a small amount of polyethylene oxide

Andrey Filippov; Bulat Munavirov; Bulat Gizatullin; Oleg N Antzutkin

doi:10.1002/mrc.3900

Disordering of phospholipid headgroups induced by a small amount of polyethylene oxide

Magn Reson Chem. 2013 Jan;51(1):1-3. doi: 10.1002/mrc.3900. Epub 2012 Nov 7.

Authors

Andrey Filippov¹, Bulat Munavirov, Bulat Gizatullin, Oleg N Antzutkin

Affiliation

¹ Kazan (Volga Region) Federal University, 420008, Kazan, Russian Federation. Andrey.Filippov@ksu.ru

PMID: 23132677
DOI: 10.1002/mrc.3900

Abstract

We present a (31)P NMR spectroscopy study of planar glass-plate-oriented multi-bilayers of dimyristoylphosphatidylcholine (DMPC) with addition of polyethylene oxide (PEO). This work revealed the presence of a new component in the spectra that appeared only with addition of a small fraction of PEO (up to one PEO segment per dimyristoylphosphatidylcholine molecule) and disappeared when larger amounts of PEO were added. We explained this phenomenon as an effect of an inhomogeneous force field induced by the PEO molecules located at a certain depth in the lipid membrane interface region.