Tracking the bioreduction of disulfide-containing cationic dendrimers

Angew Chem Int Ed Engl. 2012 Dec 7;51(50):12454-8. doi: 10.1002/anie.201207070. Epub 2012 Nov 5.

Abstract

Disulfides enhance the transfection efficacy and reduce the toxicity of cationic gene delivery polymers. A quantitative analysis is provided of the bioreduction of a dynamic bioreducible dendritic polycationic probe in four cell lines. Such knowledge is indispensible for understanding and optimizing bioreducible drug and gene delivery systems.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Boron Compounds / chemistry
  • Caco-2 Cells
  • Cations / chemistry
  • Cell Line, Tumor
  • Dendrimers / chemistry*
  • Disulfides / chemistry*
  • Drug Carriers / chemistry
  • HeLa Cells
  • Humans
  • Microscopy, Confocal
  • Oxidation-Reduction
  • Plasmids / genetics
  • Plasmids / metabolism
  • Polyamines / chemistry
  • Polymers / chemistry
  • Transfection

Substances

  • 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene
  • Boron Compounds
  • Cations
  • Dendrimers
  • Disulfides
  • Drug Carriers
  • PAMAM Starburst
  • Poly(amidoamine)
  • Polyamines
  • Polymers