Abstract
Disulfides enhance the transfection efficacy and reduce the toxicity of cationic gene delivery polymers. A quantitative analysis is provided of the bioreduction of a dynamic bioreducible dendritic polycationic probe in four cell lines. Such knowledge is indispensible for understanding and optimizing bioreducible drug and gene delivery systems.
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Boron Compounds / chemistry
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Caco-2 Cells
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Cations / chemistry
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Cell Line, Tumor
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Dendrimers / chemistry*
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Disulfides / chemistry*
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Drug Carriers / chemistry
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HeLa Cells
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Humans
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Microscopy, Confocal
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Oxidation-Reduction
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Plasmids / genetics
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Plasmids / metabolism
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Polyamines / chemistry
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Polymers / chemistry
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Transfection
Substances
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4,4-difluoro-4-bora-3a,4a-diaza-s-indacene
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Boron Compounds
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Cations
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Dendrimers
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Disulfides
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Drug Carriers
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PAMAM Starburst
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Poly(amidoamine)
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Polyamines
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Polymers