Abstract
A one-step synthesis of two 5-CF(3) UDP-sugars is reported. These non-natural sugar-nucleotides are micromolar inhibitors of two different galactosyltransferases.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Catalytic Domain / drug effects
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Enzyme Inhibitors / chemical synthesis*
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / pharmacology*
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Glycosyltransferases / antagonists & inhibitors*
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Glycosyltransferases / metabolism
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Molecular Structure
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Structure-Activity Relationship
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Uridine Diphosphate Galactose / chemical synthesis*
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Uridine Diphosphate Galactose / chemistry
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Uridine Diphosphate Galactose / pharmacology*
Substances
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Enzyme Inhibitors
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Uridine Diphosphate Galactose
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Glycosyltransferases