One-step synthesis of novel glycosyltransferase inhibitors

Chem Commun (Camb). 2012 Dec 18;48(97):11856-8. doi: 10.1039/c2cc36798j.

Abstract

A one-step synthesis of two 5-CF(3) UDP-sugars is reported. These non-natural sugar-nucleotides are micromolar inhibitors of two different galactosyltransferases.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalytic Domain / drug effects
  • Enzyme Inhibitors / chemical synthesis*
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology*
  • Glycosyltransferases / antagonists & inhibitors*
  • Glycosyltransferases / metabolism
  • Molecular Structure
  • Structure-Activity Relationship
  • Uridine Diphosphate Galactose / chemical synthesis*
  • Uridine Diphosphate Galactose / chemistry
  • Uridine Diphosphate Galactose / pharmacology*

Substances

  • Enzyme Inhibitors
  • Uridine Diphosphate Galactose
  • Glycosyltransferases