In vitro selection of a photo-responsive peptide aptamer using ribosome display

Chem Commun (Camb). 2012 Dec 18;48(97):11871-3. doi: 10.1039/c2cc36618e.

Abstract

A photo-responsive peptide aptamer against microbeads immobilized streptavidin was isolated using in vitro selection combined with photo-manipulation. This is the first example of the introduction of a peptide aptamer in the photo-control of dynamic molecular recognition.

MeSH terms

  • Amino Acid Sequence
  • Aptamers, Peptide / analysis*
  • Aptamers, Peptide / chemistry
  • Aptamers, Peptide / genetics
  • Aptamers, Peptide / radiation effects*
  • Gene Library
  • Molecular Sequence Data
  • Photochemical Processes
  • RNA, Transfer / genetics
  • Ribosomes / genetics*
  • Ribosomes / metabolism*

Substances

  • Aptamers, Peptide
  • RNA, Transfer