Abstract
A new butyrolactone, 7″-hydroxybutyrolactone III (1) and three new cycloheptanetriones, terretrione A-C (2-4), together with five known compounds, butyrolactone I, cyclo(Leu-Pro), cyclo(Val-Pro), cyclo(Ile-Pro), cyclo(Phe-Pro), were isolated from mangrove-associated marine fungus Aspergillus terreus. The structures of these compounds were elucidated on the basis of physical data analysis (NMR, high resolution-electrospray ionization (HR-ESI)-MS), especially by 2D-NMR techniques. These compounds showed weak cytotoxicity in vitro against HCT-8, Bel-7402, BGC-823, A2780 cell lines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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4-Butyrolactone / analogs & derivatives*
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4-Butyrolactone / isolation & purification
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4-Butyrolactone / pharmacology
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / pharmacology
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Aspergillus / chemistry*
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Azepines
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Cell Line, Tumor
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Cell Survival / drug effects
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Humans
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Magnetic Resonance Spectroscopy
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Neoplasms / drug therapy
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Spectrometry, Mass, Electrospray Ionization
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Tropolone / analogs & derivatives*
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Tropolone / chemistry
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Tropolone / isolation & purification
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Tropolone / pharmacology
Substances
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Antineoplastic Agents
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Azepines
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terretrione A
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terretrione B
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terretrione C
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Tropolone
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4-Butyrolactone