Abstract
The preparation of chiral tetrahydroquinolines using Ir-catalysed asymmetric hydrogenation and their possible cytotoxic potential anti-cancer activity were reported. Both of the in vitro cytotoxicity assay on a series of human cancer cell lines including A549 small cell lung cancer, MDA-MB-231 breast cancer, SaoS2 sacroma, SKHep-1 hepatoma and Hep3B hepatocellular carcinoma as well as in vivo animal model using Hep3B hepatocellular tumour xenograft on athymic nude mice suggest that 1,2,3,4-tetrahydroquin-8-ol is a potential anti-tumour alkaloid which may be further developed as a novel cancer chemotherapeutic agent.
Copyright © 2012 Elsevier GmbH. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Breast Neoplasms / drug therapy
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Female
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Humans
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Hydroxyquinolines / chemical synthesis*
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Hydroxyquinolines / chemistry
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Hydroxyquinolines / pharmacology*
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Liver Neoplasms, Experimental / drug therapy*
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Mice
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Mice, Nude
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Plant Extracts / chemical synthesis
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Plant Extracts / chemistry
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Plant Extracts / pharmacology*
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Rutaceae / chemistry*
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Sarcoma / drug therapy
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Small Cell Lung Carcinoma / drug therapy
Substances
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1,2,3,4-tetrahydroquin-8-ol
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Antineoplastic Agents
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Hydroxyquinolines
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Plant Extracts