Briacavatolides D-F, new briaranes from the Taiwanese octocoral Briareum excavatum

Mar Drugs. 2012 Sep;10(9):2103-2110. doi: 10.3390/md10092103. Epub 2012 Sep 24.

Abstract

In the continued search for novel bioactive substances from the Taiwanese octocoral Briareum excavatum collected at Orchid Island, three new briarane-type diterpenoids, briacavatolides D-F (1-3) were isolated from the acetone extract. The structures of these compounds were elucidated by extensive NMR spectroscopic analysis and physical data. The anti-HCMV (human cytomegalovirus) activity of 1-3 and their cytotoxicity against selected cancer cell lines were evaluated.

Keywords: Briareum excavatum; anti-HCMV; briarane-type diterpenoid; cytotoxicity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anthozoa / chemistry*
  • Antiviral Agents / chemistry
  • Antiviral Agents / pharmacology
  • Aquatic Organisms / chemistry*
  • Biological Products / chemistry*
  • Biological Products / pharmacology*
  • Cell Line, Tumor
  • Cytomegalovirus / drug effects
  • Diterpenes / chemistry*
  • Diterpenes / pharmacology*
  • HT29 Cells
  • Humans
  • Magnetic Resonance Spectroscopy / methods
  • Mice
  • Taiwan

Substances

  • Antiviral Agents
  • Biological Products
  • Diterpenes