Abstract
Diabetes mellitus encompasses two distinct disease processes: autoimmune Type 1 (T1D) and nonimmune Type 2 (T2D) diabetes. Despite the disparate aetiologies, the disease phenotype of hyperglycemia and the associated complications are similar. In this paper, we discuss the role of the CD39-adenosinergic axis in the pathogenesis of both T1D and T2D, with particular emphasis on the role of CD39 and CD73.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Adenosine / metabolism*
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Animals
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Antigens, CD / metabolism*
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Apyrase / metabolism*
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Diabetes Mellitus, Type 1 / etiology*
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Diabetes Mellitus, Type 1 / metabolism*
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Diabetes Mellitus, Type 1 / pathology
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Diabetes Mellitus, Type 2 / etiology*
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Diabetes Mellitus, Type 2 / metabolism*
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Diabetes Mellitus, Type 2 / pathology
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Humans
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Pancreas / enzymology
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Pancreas / pathology
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Signal Transduction*
Substances
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Antigens, CD
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Apyrase
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CD39 antigen
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Adenosine