Potentiation of hemostimulating effects of erythropoietin with pegylated hyaluronate-endo-β-N-acetylhexosaminidase

Bull Exp Biol Med. 2012 Sep;153(5):684-8. doi: 10.1007/s10517-012-1799-0.

Abstract

Pegylated hyaluronate-endo-β-N-acetylhexosaminidase considerably potentiates the hemostimulating effects of erythropoietin due to intensification of proliferation and differentiation of erythroid precursors against the background of enhanced secretion of hemopoietins by nonadherent hemopoiesis-inducing environment cells and elevation of serum erythropoietin concentration. The use of the enzyme allows 10-fold reduction of the maximum effective erythropoietin dose.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anemia / drug therapy*
  • Animals
  • Carboplatin
  • Dose-Response Relationship, Drug
  • Drug Synergism
  • Enzyme-Linked Immunosorbent Assay
  • Erythrocyte Count
  • Erythropoietin / blood
  • Erythropoietin / metabolism*
  • Erythropoietin / pharmacology*
  • Female
  • Hemoglobins / metabolism
  • Male
  • Mice
  • Mice, Inbred CBA
  • Nanotechnology / methods
  • Polyethylene Glycols / metabolism*
  • Recombinant Proteins
  • Statistics, Nonparametric
  • beta-N-Acetylhexosaminidases / metabolism*

Substances

  • Hemoglobins
  • Recombinant Proteins
  • epoetin beta
  • Erythropoietin
  • Polyethylene Glycols
  • Carboplatin
  • beta-N-Acetylhexosaminidases