Tacrine-6-ferulic acid, a novel multifunctional dimer against Alzheimer's disease, prevents oxidative stress-induced neuronal death through activating Nrf2/ARE/HO-1 pathway in HT22 cells

CNS Neurosci Ther. 2012 Nov;18(11):950-1. doi: 10.1111/cns.12010.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alzheimer Disease* / metabolism
  • Alzheimer Disease* / prevention & control
  • Animals
  • Cell Death / drug effects
  • Cell Death / physiology
  • Cell Line, Transformed
  • Coumaric Acids / chemistry
  • Coumaric Acids / pharmacology*
  • Coumaric Acids / therapeutic use
  • Heme Oxygenase-1 / biosynthesis*
  • Mice
  • NF-E2-Related Factor 2 / biosynthesis*
  • Neurons / drug effects
  • Neurons / metabolism
  • Oxidative Stress / drug effects*
  • Oxidative Stress / physiology
  • Protein Multimerization / drug effects
  • Protein Multimerization / physiology
  • Regulatory Elements, Transcriptional / drug effects*
  • Regulatory Elements, Transcriptional / physiology
  • Signal Transduction / drug effects
  • Signal Transduction / physiology
  • Tacrine / analogs & derivatives*
  • Tacrine / chemistry
  • Tacrine / pharmacology
  • Tacrine / therapeutic use

Substances

  • Coumaric Acids
  • NF-E2-Related Factor 2
  • NFE2L2 protein, human
  • tacrine-6-ferulic acid
  • Tacrine
  • HMOX1 protein, human
  • Heme Oxygenase-1