Two new compounds from an endophytic fungus Alternaria solani

J Asian Nat Prod Res. 2012;14(12):1144-8. doi: 10.1080/10286020.2012.733701. Epub 2012 Oct 29.

Abstract

Two new secondary metabolites, named 7-dehydroxyl-zinniol (1) and 20-hydroxyl-ergosta-4,6,8(14),22-tetraen-3-one (2), were isolated from the culture of Alternaria solani, an endophytic fungal strain residing in the roots of Aconitum transsectum. Their structures were elucidated on the basis of comprehensive spectroscopic analyses including IR, ESI-MS, HR-ESI-MS, 1D and 2D NMR. Biological activity tests indicated that compound 1 showed moderate anti-HBV activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aconitum / microbiology
  • Alternaria / chemistry*
  • Cholestenones / chemistry
  • Cholestenones / isolation & purification*
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Plant Roots / microbiology
  • Xylenes / chemistry
  • Xylenes / isolation & purification*

Substances

  • 20-hydroxyl-ergosta-4,6,8(14),22-tetraen-3-one
  • 7-dehydroxyl-zinniol
  • Cholestenones
  • Xylenes
  • ergosta-4,6,8(14),22-tetraen-3-one