Decline in macrolide-resistant Streptococcus pyogenes isolates from French children

Int J Med Microbiol. 2012 Dec;302(7-8):300-3. doi: 10.1016/j.ijmm.2012.09.001. Epub 2012 Oct 25.

Abstract

We studied the macrolide resistance and serotypes of 585 group A streptococcus (GAS) isolates collected from French children with pharyngitis. Nineteen isolates (3.2%) were erythromycin-resistant and harbored the following resistance genes: 31.6% mef(A), 15.8% erm(A), and 52.6% erm(B). The 19 isolates included 7 different emm types (4, 1, 11, 2, 28, 12, and 77) and 7 corresponding multilocus sequence types. The current fall in macrolide consumption has led to a very low rate of GAS macrolide resistance.

MeSH terms

  • Adolescent
  • Anti-Bacterial Agents / pharmacology*
  • Child
  • Child, Preschool
  • Cluster Analysis
  • Drug Resistance, Bacterial*
  • France / epidemiology
  • Genes, Bacterial
  • Genotype
  • Humans
  • Macrolides / pharmacology*
  • Multilocus Sequence Typing
  • Pharyngitis / epidemiology*
  • Pharyngitis / microbiology
  • Prevalence
  • Serotyping
  • Streptococcal Infections / epidemiology*
  • Streptococcal Infections / microbiology
  • Streptococcus pyogenes / classification
  • Streptococcus pyogenes / drug effects*
  • Streptococcus pyogenes / isolation & purification
  • Virulence Factors / genetics

Substances

  • Anti-Bacterial Agents
  • Macrolides
  • Virulence Factors