Abstract
We studied the macrolide resistance and serotypes of 585 group A streptococcus (GAS) isolates collected from French children with pharyngitis. Nineteen isolates (3.2%) were erythromycin-resistant and harbored the following resistance genes: 31.6% mef(A), 15.8% erm(A), and 52.6% erm(B). The 19 isolates included 7 different emm types (4, 1, 11, 2, 28, 12, and 77) and 7 corresponding multilocus sequence types. The current fall in macrolide consumption has led to a very low rate of GAS macrolide resistance.
Copyright © 2012 Elsevier GmbH. All rights reserved.
MeSH terms
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Adolescent
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Anti-Bacterial Agents / pharmacology*
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Child
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Child, Preschool
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Cluster Analysis
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Drug Resistance, Bacterial*
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France / epidemiology
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Genes, Bacterial
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Genotype
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Humans
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Macrolides / pharmacology*
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Multilocus Sequence Typing
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Pharyngitis / epidemiology*
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Pharyngitis / microbiology
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Prevalence
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Serotyping
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Streptococcal Infections / epidemiology*
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Streptococcal Infections / microbiology
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Streptococcus pyogenes / classification
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Streptococcus pyogenes / drug effects*
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Streptococcus pyogenes / isolation & purification
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Virulence Factors / genetics
Substances
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Anti-Bacterial Agents
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Macrolides
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Virulence Factors