Macrolides: the plug is out

Martin Gamerdinger; Elke Deuerling

doi:10.1016/j.cell.2012.10.015

Macrolides: the plug is out

Cell. 2012 Oct 26;151(3):469-71. doi: 10.1016/j.cell.2012.10.015.

Authors

Martin Gamerdinger¹, Elke Deuerling

Affiliation

¹ Molecular Microbiology, Department of Biology, University of Konstanz, 78457 Konstanz, Germany.

PMID: 23101618
DOI: 10.1016/j.cell.2012.10.015

Abstract

Macrolide antibiotics are thought to clog up the ribosomal tunnel and thereby block general protein synthesis. By using a combination of elegant in vivo and in vitro approaches, Kannan et al. show that the inhibitory action of these drugs on bacterial protein synthesis is selective rather than global.

Publication types

Comment
Research Support, Non-U.S. Gov't