A novel furanoeremophilane with an unusual oxygen bridge from Senecio nemorensis

Baojun Shi; Ji Shi; Hongfang Jiang; Guixin Chou; Zhengtao Wang

doi:10.1016/j.fitote.2012.10.005

A novel furanoeremophilane with an unusual oxygen bridge from Senecio nemorensis

Fitoterapia. 2013 Jan:84:11-4. doi: 10.1016/j.fitote.2012.10.005. Epub 2012 Oct 23.

Authors

Baojun Shi¹, Ji Shi, Hongfang Jiang, Guixin Chou, Zhengtao Wang

Affiliation

¹ Nanjing Institute for Comprehensive Utilization of Wild Plant, Nanjing 210042, China; China Pharmaceutical University, Nanjing 210009, China.

PMID: 23098879
DOI: 10.1016/j.fitote.2012.10.005

Abstract

Two new furanoeremophilanes, 1α, 6α-epoxy-9-oxo-10β-hydroxyl-furanoeremophilane (1), and 9-oxo-1α, 6β, 10β-trihydroxy-furanoeremophilane (2) were isolated from Senecio nemorensis. Their structures were elucidated by spectroscopic methods and X-ray crystallography. This is the first report of the isolation of the C1-C6 oxygen bridge of furanoeremophilane. Their cytotoxic effects on BEL7402 and NF-KB cell lines were tested.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents, Phytogenic / chemistry*
Antineoplastic Agents, Phytogenic / pharmacology*
Cell Line, Tumor
Humans
Models, Molecular
Molecular Structure
Oxygen / chemistry*
Polycyclic Sesquiterpenes
Senecio / chemistry*
Sesquiterpenes / chemistry*
Sesquiterpenes / pharmacology*

Substances

1alpha,6alpha-epoxy-9-oxo-10beta-hydroxyl-furanoeremophilane
9-oxo-1alpha,6beta,10beta-trihydroxy-furanoeremophilane
Antineoplastic Agents, Phytogenic
Polycyclic Sesquiterpenes
Sesquiterpenes
Oxygen