The concept of quality of life has many meanings, is variously defined, understood and tested. There is no universal, generally accepted definition of quality of life, but all of the ways to understand this construct have common features--quality of life is subjective, it is associated with health but its meaning is much broader and multidimensional by involving multiple clinical, functional and social variables. In the last decade, followed by redefining the concept of health as a positive resource it is recommended to perceive the quality of life holistically, including both--satisfaction with life in general and satisfaction with its particular domains. The study is an attempt to present the matter of quality of life in the most synthetic way possible, to the extent allowed by its complexity.