Design of highly potent HIV fusion inhibitors based on artificial peptide sequences

Weiguo Shi; Lifeng Cai; Lu Lu; Chao Wang; Kun Wang; Liang Xu; Sha Zhang; Han Han; Xifeng Jiang; Baohua Zheng; Shibo Jiang; Keliang Liu

doi:10.1039/c2cc35973a

Design of highly potent HIV fusion inhibitors based on artificial peptide sequences

Chem Commun (Camb). 2012 Dec 7;48(94):11579-81. doi: 10.1039/c2cc35973a.

Authors

Weiguo Shi¹, Lifeng Cai, Lu Lu, Chao Wang, Kun Wang, Liang Xu, Sha Zhang, Han Han, Xifeng Jiang, Baohua Zheng, Shibo Jiang, Keliang Liu

Affiliation

¹ Department of Medicinal Chemistry, Beijing Institute of Pharmacology & Toxicology, 27 Taiping Rd, Haidian District, Beijing 100850, China.

PMID: 23093045
DOI: 10.1039/c2cc35973a

Abstract

Specific interactions were introduced between an artificial heptad repeat peptide template and HIV-1 gp41 for fusion inhibitor design, using a structure based rational design strategy. The designed peptides are nonhomologous with naturally occurring peptide and protein sequences, specifically interact with HIV-1 gp41, and show strong anti-HIV activity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Sequence
Anti-HIV Agents / chemistry
Anti-HIV Agents / pharmacology*
Drug Design*
HIV Envelope Protein gp41 / chemistry
HIV-1 / drug effects
HIV-1 / physiology*
Molecular Sequence Data
Peptidomimetics / chemistry
Peptidomimetics / pharmacology*
Repetitive Sequences, Amino Acid
Virus Internalization / drug effects*

Substances

Anti-HIV Agents
HIV Envelope Protein gp41
Peptidomimetics
gp41 protein, Human immunodeficiency virus 1