Abstract
The dipolar cycloadditions of ortho-nitrophenyl alkynes with aryl nitrile oxides has been demonstrated. A range of substituents are tolerated on the alkyne. These reactions proceed with excellent levels of regioselectivity. Subsequent functionalization of the isoxazole scaffold has been demonstrated.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Alkynes / chemistry*
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Amides / chemical synthesis*
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Catalysis
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Cycloaddition Reaction
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Isoxazoles / chemical synthesis*
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Magnetic Resonance Spectroscopy
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Nitriles / chemistry*
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Oxides / chemistry*
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Oximes / chemical synthesis*
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Stereoisomerism
Substances
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Alkynes
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Amides
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Isoxazoles
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Nitriles
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Oxides
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Oximes