Hot-melt coating with lipid excipients

Abstract

Polymer coatings are widely used to provide drug protection, taste masking, coloration and modified drug release. Typically, coating polymers must be diluted or dispersed in solvents (water or organic) prior to coating and gliding agents are commonly added to prevent particle sticking throughout processing. Lipid excipients present an attractive alternative to standard polymer coatings as they only require melting before application directly onto the substrate. Solvent evaporation is not required; consequently powders with very high specific surface areas can be coated rapidly. A number of different lipid excipients can be used in coating and choosing the appropriate excipient for the application requires an understanding of their physico-chemical properties and its associated effect on drug release.

Keywords: Controlled release; Fluid bed coater; Hot-melt coating; Lipid coating; Taste masking.