Organocatalytic asymmetric biomimetic transamination of aromatic ketone to optically active amine

Ying Xie; Hongjie Pan; Xiao Xiao; Songlei Li; Yian Shi

doi:10.1039/c2ob26782a

Organocatalytic asymmetric biomimetic transamination of aromatic ketone to optically active amine

Org Biomol Chem. 2012 Dec 7;10(45):8960-2. doi: 10.1039/c2ob26782a. Epub 2012 Oct 22.

Authors

Ying Xie¹, Hongjie Pan, Xiao Xiao, Songlei Li, Yian Shi

Affiliation

¹ Beijing National Laboratory of Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.

PMID: 23086578
DOI: 10.1039/c2ob26782a

Abstract

An asymmetric biomimetic transamination of aromatic ketones to optically active amines with o-HOPhCH(2)NH(2) as amine source catalyzed by hydroquinine-derived chiral base is described. Up to 85% ee was obtained.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amines / chemistry*
Biomimetics*
Catalysis
Ketones / chemistry*
Optical Phenomena*

Substances

Amines
Ketones