18F labeling of arenes

Angew Chem Int Ed Engl. 2012 Nov 12;51(46):11426-37. doi: 10.1002/anie.201204687. Epub 2012 Oct 19.

Abstract

Molecular imaging has witnessed an upsurge in growth, with positron emission tomography leading the way. This trend has encouraged numerous synthetic chemists to enter the field of (18) F-radiochemistry and provide generic solutions to address the well-recognized challenges of late-stage fluorination. This Minireview focuses on recent developments in the (18)F-labeling of aromatic substrates.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Fluorine Radioisotopes / chemistry*
  • Halogenation
  • Humans
  • Hydrocarbons, Aromatic / chemical synthesis
  • Hydrocarbons, Aromatic / chemistry*
  • Molecular Imaging / methods
  • Positron-Emission Tomography / methods

Substances

  • Fluorine Radioisotopes
  • Hydrocarbons, Aromatic