A structure-activity relationship study for 2'-deoxyadenosine analogs at A9 position in the catalytic core of 10-23 DNAzyme for rate enhancement

Nucleic Acid Ther. 2012 Dec;22(6):423-7. doi: 10.1089/nat.2012.0365. Epub 2012 Oct 19.

Abstract

Modification on the catalytic core of 10-23 DNAzyme with protein-like functional groups is a potential approach to obtain its more efficient analogs. In our efforts for this purpose, a lead structure (DZ-2-9) with 8-aza-7-deaza-2'-deoxyadenosine at the A9 position in its catalytic core was obtained. Here we report our structure-activity relationship studies on this lead structure. Various functional groups of different chemical properties were introduced through the 7-substituents of 8-aza-7-deaza-2'-deoxyadenosine to DZ-2-9. The functional groups capable of forming hydrogen bonds, like amino and hydroxyl groups, are more favorable for catalytic rate enhancement than the large groups with spacial occupation, like phenyl and tert-butylphenyl groups, and the flexible alkyl linkage was the more preferred choice for optimizing their positive effect. Furthermore, they exerted positive effect cooperatively with the N8 atom. These results give us a clear hint in the design of compounds for A9 substitution of 10-23 DNAzyme for more efficient DNAzymes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalytic Domain
  • DNA, Catalytic / chemistry*
  • DNA, Single-Stranded / chemistry*
  • Deoxyadenosines / chemistry*
  • Enzyme Activators / chemistry*
  • Hydrophobic and Hydrophilic Interactions
  • Kinetics
  • RNA Cleavage
  • Structure-Activity Relationship

Substances

  • DNA, Catalytic
  • DNA, Single-Stranded
  • Deoxyadenosines
  • Enzyme Activators
  • RNA-cleaving DNA 10-23