Phase-sensitive OCT imaging of multiple nanoparticle species using spectrally multiplexed single pulse photothermal excitation

Sanghoon Kim; Matthew T Rinehart; Hansang Park; Yizheng Zhu; Adam Wax

doi:10.1364/BOE.3.002579

Phase-sensitive OCT imaging of multiple nanoparticle species using spectrally multiplexed single pulse photothermal excitation

Biomed Opt Express. 2012 Oct 1;3(10):2579-86. doi: 10.1364/BOE.3.002579. Epub 2012 Sep 17.

Authors

Sanghoon Kim¹, Matthew T Rinehart, Hansang Park, Yizheng Zhu, Adam Wax

Affiliation

¹ Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.

Abstract

We apply phase-sensitive optical coherence tomography to image multiple nanoparticle species with two excitation wavelengths matched to their distinct absorption peaks. Using different modulation frequencies, multiple species collocated within the sample can be distinguished. In addition, we characterize single-pulse excitation schemes as a method to minimize bulk heating of the sample. We demonstrate this new scheme with B-mode photothermal measurements of tissue phantoms.

Keywords: (110.3000) Image quality assessment; (160.4236) Nanomaterials; (170.4500) Optical coherence tomography.