Methylome alterations "mark" new therapeutic opportunities in glioblastoma

Eric H Raabe; Charles G Eberhart

doi:10.1016/j.ccr.2012.10.001

Methylome alterations "mark" new therapeutic opportunities in glioblastoma

Cancer Cell. 2012 Oct 16;22(4):417-8. doi: 10.1016/j.ccr.2012.10.001.

Authors

Eric H Raabe¹, Charles G Eberhart

Affiliation

¹ Division of Pediatric Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. eraabe2@jhmi.edu

Abstract

In this issue of Cancer Cell, Sturm et al. report that global DNA methylation patterns in glioblastoma multiforme divide adult and pediatric tumors into subgroups that have characteristic DNA mutations, mRNA profiles, and most importantly, different clinical behaviors. These findings suggest novel opportunities for therapeutics for this dreaded disease.

Publication types

Comment

Abstract

Publication types

Grants and funding