VEGF-initiated angiogenesis and the uPA/uPAR system

Cell Adh Migr. 2012 Nov-Dec;6(6):535-615. doi: 10.4161/cam.22243. Epub 2012 Oct 17.

Abstract

Angiogenesis involves a series of tightly regulated cellular processes initiated primarily by the vascular endothelial growth factor (VEGF). The urokinase-type plasminogen activator system, consisting of the urokinase-type plasminogen activator (uPA), its cellular receptor uPAR and its inhibitor PAI-1, participates in the realization of these VEGF-induced processes by activating pericellular proteolysis, increasing vascular permeability and by supporting endothelial cell proliferation and migration.

Publication types

  • Review

MeSH terms

  • Animals
  • Capillary Permeability
  • Cell Movement
  • Cell Proliferation
  • Endothelial Cells / metabolism
  • Endothelial Cells / pathology
  • Enzyme Activation
  • Humans
  • Integrin alpha Chains / metabolism
  • MAP Kinase Signaling System
  • Mice
  • Neovascularization, Pathologic / genetics
  • Neovascularization, Pathologic / metabolism*
  • Neovascularization, Pathologic / pathology
  • Plasminogen Activator Inhibitor 1 / genetics
  • Plasminogen Activator Inhibitor 1 / metabolism
  • Protein Binding
  • Protein Interaction Mapping
  • Proteolysis
  • Receptors, Urokinase Plasminogen Activator / genetics
  • Receptors, Urokinase Plasminogen Activator / metabolism*
  • Urokinase-Type Plasminogen Activator / genetics
  • Urokinase-Type Plasminogen Activator / metabolism*
  • Vascular Endothelial Growth Factor A / genetics
  • Vascular Endothelial Growth Factor A / metabolism*

Substances

  • Integrin alpha Chains
  • Plasminogen Activator Inhibitor 1
  • Receptors, Urokinase Plasminogen Activator
  • Vascular Endothelial Growth Factor A
  • vascular endothelial growth factor A, mouse
  • Urokinase-Type Plasminogen Activator