Abstract
Angiogenesis involves a series of tightly regulated cellular processes initiated primarily by the vascular endothelial growth factor (VEGF). The urokinase-type plasminogen activator system, consisting of the urokinase-type plasminogen activator (uPA), its cellular receptor uPAR and its inhibitor PAI-1, participates in the realization of these VEGF-induced processes by activating pericellular proteolysis, increasing vascular permeability and by supporting endothelial cell proliferation and migration.
MeSH terms
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Animals
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Capillary Permeability
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Cell Movement
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Cell Proliferation
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Endothelial Cells / metabolism
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Endothelial Cells / pathology
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Enzyme Activation
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Humans
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Integrin alpha Chains / metabolism
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MAP Kinase Signaling System
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Mice
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Neovascularization, Pathologic / genetics
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Neovascularization, Pathologic / metabolism*
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Neovascularization, Pathologic / pathology
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Plasminogen Activator Inhibitor 1 / genetics
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Plasminogen Activator Inhibitor 1 / metabolism
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Protein Binding
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Protein Interaction Mapping
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Proteolysis
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Receptors, Urokinase Plasminogen Activator / genetics
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Receptors, Urokinase Plasminogen Activator / metabolism*
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Urokinase-Type Plasminogen Activator / genetics
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Urokinase-Type Plasminogen Activator / metabolism*
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Vascular Endothelial Growth Factor A / genetics
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Vascular Endothelial Growth Factor A / metabolism*
Substances
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Integrin alpha Chains
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Plasminogen Activator Inhibitor 1
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Receptors, Urokinase Plasminogen Activator
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Vascular Endothelial Growth Factor A
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vascular endothelial growth factor A, mouse
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Urokinase-Type Plasminogen Activator