Abstract
High-dose intravenous immunoglobulin (IVIG) therapy is used in patients with severe autoimmune blistering diseases that are refractory to standard immunosuppressive therapy. To determine the efficacy and frequency of adverse events of IVIG therapy, we retrospectively analysed data for 16 patients with pemphigus vulgaris, pemphigus foliaceus, paraneoplastic pemphigus, bullous pemphigoid and paraneoplastic bullous pemphigoid. Frequency of adverse reactions and efficacy of IVIG were analysed over time with a scoring system for every 6 months of IVIG therapy. Headache (43.8%) and fatigue (43.8%) were the most common side-effects recorded; serious adverse reactions did not occur. There was good overall efficacy, as measured by clinical response rates using a clinical score, as well as indicated by a mean reduction of 75.8% in the starting steroid dose.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Drug Therapy, Combination
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Fatigue / chemically induced
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Female
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Headache / chemically induced
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Humans
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Immunoglobulins, Intravenous / administration & dosage*
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Immunoglobulins, Intravenous / adverse effects
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Immunologic Factors / administration & dosage*
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Immunologic Factors / adverse effects
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Immunosuppressive Agents / administration & dosage
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Male
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Middle Aged
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Paraneoplastic Syndromes / diagnosis
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Paraneoplastic Syndromes / drug therapy*
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Paraneoplastic Syndromes / immunology
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Pemphigoid, Bullous / diagnosis
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Pemphigoid, Bullous / drug therapy*
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Pemphigoid, Bullous / immunology
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Pemphigus / diagnosis
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Pemphigus / drug therapy*
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Pemphigus / immunology
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Retrospective Studies
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Steroids / administration & dosage
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Time Factors
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Treatment Outcome
Substances
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Immunoglobulins, Intravenous
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Immunologic Factors
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Immunosuppressive Agents
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Steroids