Abstract
During nervous system development, programmed cell death is considered as an essential adaptive process. The mechanism by which the number of mature neurons is determined in the central nervous system is not well understood. In a recent Nature paper, Southwell et al (2012) demonstrate that cortical GABAergic interneuron cell death is intrinsically determined without the need to compete for extrinsic survival signals derived from other cell types.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Brain Mapping / methods
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Cell Death
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Developmental Biology / methods
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GABA Agents / metabolism
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Gap Junctions
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Green Fluorescent Proteins / metabolism
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Interneurons / physiology*
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Mice
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Models, Biological
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Models, Neurological
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Neocortex / metabolism
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Nervous System / embryology
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Neurons / metabolism
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Signal Transduction
Substances
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GABA Agents
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Green Fluorescent Proteins