From basic biology to randomized clinical trial: the Beta Radiation for Arteriovenous Graft Outflow Stenosis (BRAVO II)

Semin Dial. 2013 Mar-Apr;26(2):227-32. doi: 10.1111/sdi.12000. Epub 2012 Oct 16.

Abstract

The BRAVO-II study was a randomized controlled study of endovascular radiation therapy as compared to sham radiation therapy, following angioplasty of a thrombosed PRFE graft. The results did not show a benefit of endovascular radiation therapy, albeit in the context of an early termination of the study at less than 50% enrollment due to business reasons. Emphasis is laid on the fact that there may still be a role for radiation therapy in specific clinical settings associated with dialysis vascular access dysfunction.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Angioplasty
  • Arteriovenous Shunt, Surgical
  • Beta Particles
  • Brachytherapy / methods*
  • Double-Blind Method
  • Female
  • Graft Occlusion, Vascular / radiotherapy*
  • Humans
  • Male
  • Middle Aged
  • Multicenter Studies as Topic
  • Placebos
  • Randomized Controlled Trials as Topic
  • Renal Dialysis*
  • Treatment Outcome
  • Vascular Patency

Substances

  • Placebos