Medication detection by a combinatorial fluorescent molecular sensor

Angew Chem Int Ed Engl. 2012 Dec 7;51(50):12477-81. doi: 10.1002/anie.201206374. Epub 2012 Oct 12.

Abstract

Working together to uncover the truth: A molecule-sized diagnostic system combining several recognition elements and four fluorescence-emission channels enabled the identification of a wide range of pharmaceuticals on the basis of distinct photophysical processes. The molecular sensor (see simplified representation; ID = identification) was also used to analyze drug concentrations and combinations in urine samples in a high-throughput manner.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / analysis
  • Anti-Bacterial Agents / urine
  • Electron Transport
  • Fluorescence Resonance Energy Transfer*
  • Fluorescent Dyes / chemistry
  • Humans
  • Molecular Conformation
  • Pharmaceutical Preparations / analysis*
  • Pharmaceutical Preparations / urine
  • Point-of-Care Systems
  • Principal Component Analysis

Substances

  • Anti-Bacterial Agents
  • Fluorescent Dyes
  • Pharmaceutical Preparations